- What is Paget disease and what are the symptoms?
- What does Paget’s disease feel like?
- What is the prognosis for Paget disease?
- What are the stages of Paget disease?
- How is Paget’s disease diagnosed and treated?
- What is the first line treatment for Paget disease?
- Is Paget’s disease fatal?
- How long does it take for Paget’s disease to progress?
- What is the most common age for females to be diagnosed with Paget’s disease?
- Is Paget’s disease an autoimmune disorder?
- How is Paget’s disease different from osteoporosis?
- Can Paget’s disease be cured?
- What virus causes Paget’s disease?
- Is Pagets disease serious?
- What is the survival rate for Paget disease?
What is Paget disease and what are the symptoms?
Symptoms of Paget’s disease of bone Commonly affected areas include the pelvis, spine and skull.
Symptoms can include: constant, dull bone pain.
joint pain, stiffness and swelling.
a shooting pain that travels along or across the body, numbness and tingling, or loss of movement in part of the body..
What does Paget’s disease feel like?
Symptoms of Paget’s disease of the nipple It appears as a red, scaly rash on the skin of the nipple and areola. The affected skin is often sore and inflamed, and it can be itchy or cause a burning sensation. The nipple can sometimes be ulcerated.
What is the prognosis for Paget disease?
The 5-year survival rate for a patient with Paget disease and sarcoma is 5-7.5%; however, it may be as high as 50% for those who undergo operative tumor ablation and chemotherapy before metastases occur. The 5-year survival rate for elderly patients with primary nonpagetic sarcoma is 37%.
What are the stages of Paget disease?
Three phases of Paget disease have been described: lytic, mixed lytic and blastic, and sclerotic. In an individual patient, different skeletal lesions may progress at different rates. Thus, at any one time, multiple stages of the disease may be demonstrated in different skeletal regions.
How is Paget’s disease diagnosed and treated?
During the physical exam, your doctor will examine areas of your body that are causing you pain. He or she may also order X-rays and blood tests that can help confirm the diagnosis of Paget’s disease of bone.
What is the first line treatment for Paget disease?
Bisphosphonates are first-line therapy for Paget’s disease, and the advent of the new bisphosphonates permits a dramatic improvement in treatment. The optimal treatment regimen should obtain normalisation or quasi-normalisation of markers of bone remodelling.
Is Paget’s disease fatal?
Others have symptoms and complications. Pain is the most common symptom. Depending on which of your bones are affected by Paget’s disease, you might have other symptoms and complications, such as those listed below. Although rare, the most serious complication of Paget’s disease is bone cancer.
How long does it take for Paget’s disease to progress?
As a result, diagnosis may be delayed, often up to six months or more. Most individuals with the condition eventually seek medical attention due to associated itching or burning sensations, soreness, or pain of the affected area.
What is the most common age for females to be diagnosed with Paget’s disease?
Paget’s disease of the breast occurs most often in women older than age 50. Most women with Paget’s disease of the breast have underlying ductal breast cancer, either in situ — meaning in its original place — or, less commonly, invasive breast cancer.
Is Paget’s disease an autoimmune disorder?
Paget’s disease of bone is a chronic autoimmune inflammatory disease that leads to an increase in bone reabsorption. While depression is extensively described in Paget’s disease, affecting up to 50% of patients, the prevalence of manic episodes is unknown.
How is Paget’s disease different from osteoporosis?
Paget’s disease typically is localized, affecting just one or a few bones, as opposed to osteoporosis, for example, which affects all the bones in the body. Scientists do not know for sure what causes Paget’s disease.
Can Paget’s disease be cured?
There’s currently no cure for Paget’s disease of bone, but treatment can help relieve the symptoms. If you do not have any symptoms, your doctor may suggest keeping an eye on your condition and delaying treatment until any problems occur.
What virus causes Paget’s disease?
Paget’s disease may be caused by a slow virus infection (i.e., paramyxoviridae) present for many years before symptoms appear. Associated viral infections include respiratory syncytial virus, canine distemper virus, and the measles virus.
Is Pagets disease serious?
Extensive Paget’s disease of bone may force your heart to work harder to pump blood to the affected areas of your body. Sometimes, this increased workload can lead to heart failure. Bone cancer. Bone cancer occurs in about 1 percent of people with Paget’s disease of bone.
What is the survival rate for Paget disease?
For women with both Paget disease of the breast and invasive cancer in the same breast, the 5-year relative survival declined with increasing stage of the cancer (stage I, 95.8 percent; stage II, 77.7 percent; stage III, 46.3 percent; stage IV, 14.3 percent) (1, 3, 8, 9).